Semaglutide works by mimicking the effects of insulin. This increases satiety and reduces appetite. Semaglutide is a peptide that functions as a GLP-1 receptor agonist and acts on ghrelin receptors in the brain. Ghrelin is the hormone responsible for making us feel hungry when other hormones like leptin are not blocking it. Since Semaglutide blocks ghrelin, you feel less hungry throughout the day. Further, a typical meal take 60-90 minutes to pass through the stomach. With Semaglutide, a meal can remain in the stomach for up to 7 hours with ongoing gastric stretch and sensation of fullness.